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Concomitantly, SIRT1, a central regulator of hepatic lipid and glucose homeostasis, governs metabolic flux between lipogenesis and fatty acid oxidation

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Especially, the detailed knowledge of the nanocarrier-transporter complex internalization and following sorting processes and exocytosis would enable rational design of nanocarriers capable of efficient transcytosis across the BBB by minimizing the lysosomal degradation of the nanocarrier in the endothelial cells