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Pineal-derived melatonin and de novo synthesis in the GI tract both produce melatonin which helps regulate gut immunity and intestinal barrier integrity

Journal of Neuroinflammation 9 : 106

In each well, the apical fluid was collected and the monolayer was then washed twice with PBS

Brain 136:23422358 Park JH, Elpers C, Reunert J et al (2019) SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis

The preclinical literature has described effects across multiple pathways, and mechanistic claims are better framed as a family of related observations rather than a settled mechanism

It provides sulfur groups that support immune function