391 GLP-1 and GLP-1 analogs exert their effects on food intake and body weight through a myriad of neural substrates, encompassing several hypothalamic nuclei (including the arcuate nucleus of the hypothalamus, periventricular hypothalamus, and lateral hypothalamic area), hindbrain nuclei (such as the parabrachial nucleus and medial nucleus tractus solitarius), the ventral subregion of the hippocampus (vHP), and nuclei embedded within the mesolimbic reward circuitry (including the ventral tegmental area, VTA, and nucleus accumbens, NAc)
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Trial data show comparable rates of nausea, vomiting, and diarrhea to the injectable
Alex Azar, former Secretary of the US Department of Health and Human Services, noted that there is little stigma around taking a statin to manage high cholesterol, but using a GLP-1 to help with weight loss can be perceived by some as taking the easy way out. Panelists emphasized that this perception, despite its inaccuracy, persists and may stand in the way of patients accessing these effective treatments or staying on them long-term
5, 2026, the newly approved GLP-1 pills for weight loss had been prescribed to about 170,000 people, outpacing the rate of adoption of other GLP-1 medications
