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Tirzepatide Safety in Mild to Moderate Kidney Disease Patients with mild to moderate kidney disease (eGFR 3089 mL/min/1.73m) generally tolerate tirzepatide well without dose adjustments, according to clinical trial data and real-world observational studies

This design minimizes tissue trauma and reduces nerve stimulation at the injection site

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Fast forward to 2005 and a synthetic version of exendina GLP-1 receptor agonist known as exenatide (brand name Byetta ) became the first medicine of its kind to treat type 2 diabetes

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