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Low glycemic index diets rich in monounsaturated fatty acids are associated with improvement in hepatic steatosis and ALT levels, and in a recent study, ad libitum low carbohydrate diets resulted in greater weight loss and improvement in insulin resistance compared to energy-restricted high carbohydrate diets (275277)

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The FDA-approved metformin label confirms that metformin is not bound to plasma proteins, is not metabolized, and is excreted unchanged in urine with a renal clearance approximately 3.5 times creatinine clearance [6]

Blein, C., et al

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