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Similar to Study 1419, neither of these studies included a randomized control group, undermining the ability to make meaningful inferences about the benefits and harms of treatment

"LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept"

It is generally safe as a supplement, but consult a doctor if you are pregnant or breastfeeding

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All this suggests one could titrate to the weight loss and cardiometabolic benefit needed and then either maintain at that dose or possibly dose reduce down if needed or desired