Authors: Thomas Kruse, Jakob Lerche Hansen, Kirsten Dahl, Lauge Schffer, Ulrich Sensfuss, Christian Poulsen, Morten Schlein, Ann Maria Kruse Hansen, Claus Bekker Jeppesen, Charlotta Dornonville de la Cour, Trine Ryberg Clausen, Eva Johansson, Simone Fulle, Rikke Bjerring Skyggebjerg, Kirsten Raun URL: This paper details the medicinal chemistry efforts that led to the design and synthesis of cagrilintide, a long-acting amylin analogue for the treatment of obesity
Pipeline data was extracted from diverse sources including pharmaceutical databases, clinical trial registries, scientific literature and funders grant databases following our pipeline methodology
Rapid photodegradation was observed under UVVIS radiation, while application of VIS radiation did not affect drug molecules
S-Acetyl-Glutathione is the first stable form of glutathione, meaning it resists stomach acid and reaches the cells
Getting around Long Beach means dealing with the 710 and the 405, two of the most congested freeways in the country
In cells expressing HPV-16 E7 Mut, significant differences with the control were found in the SOD, catalase, and GSH-Px activities, as well as in the total GSH content, while significant differences with HPV-16 E7-expressing cells were only observed in regards to TBARS and GSH-Px