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Additionally, the serotonin pathway of Trp metabolism plays a crucial role in the regulation of mood and mental health, especially in depression and anxiety 78,79

What I found especially noteworthy is that the reduction appeared stronger for venous thromboembolic events than for some arterial cardiovascular outcomes such as myocardial infarction

So from a nutrient-sensing pathway, what you could infer from that is too little leucine, probably a bad thing, too much leucine, probably a bad thing

Safety data from trials In a paper summarizing 6 randomized, double-blind, placebo-controlled human trials, AOD 9604 did not significantly affect IGF-1 levels, did not impair glucose tolerance, and no serious adverse events (SAEs) were attributed to AOD 9604

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[DOI] [PubMed] [Google Scholar] 155.Lushchak VI