A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study
For people whose hair loss is driven by rapid weight reduction and nutritional deficiency, the approach needs to focus on slowing the pace and filling nutritional gaps

Embla coaches work with members to: Set achievable goals and build consistency in daily behaviors Identify and defuse unhelpful thoughts and food-related coping patterns Prepare for plateaus and relapses and navigate through them Develop the confidence and skills to maintain weight loss for life Real-world outcomes: what employers should expect Employers implementing coaching-first models like Embla's can expect: Improved medication efficiency members use lower doses and taper sooner, which reduces total drug spend Higher engagement and adherence weekly video coaching drives strong retention and satisfaction Lower long-term costs less reliance on high-cost GLP-1s, fewer comorbidities, and healthier employee populations Transparent reporting dashboards that track individual and population-level outcomes, including weight loss, medication usage, and program ROI We've worked with employers where 8085% of members stay engaged for 6+ months, and more than half continue engaging after medication has ended because they've built a trusted relationship with their coach

the aggregating alpha-synuclein also binds preferentially to mitochondria where it can disrupt energy metabolism leading to oxidative stress
This could be due to an additional effect on hepatic glucose production (245)
Weve moved well past the fear era of the early 2000s