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Upon binding to GLP-1R, GLP-1 triggers the activation of the G protein, which stimulates adenylyl cyclase [4]

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A comprehensive 2025 review by Mechanick and colleagues in Obesity Reviews estimated that participants in the major GLP-1 trials lost 10 percent or more of their muscle mass over roughly 68 to 72 weeks, which the authors compared to about 20 years' worth of age-related muscle decline packed into a little over a year (Mechanick et al., 2025)

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Common injection sites include the thigh, shoulder, and buttocks