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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists in persons with obesity and knee osteoarthritis in this population has not been well-established. To test the impact of a GLP-1 receptor weight loss medication on knee OA outcomes, Bliddal and colleagues conducted a double-blind, randomized, placebo-controlled trial at 61 sites across 11 countries

Sinus nodes were allowed to stabilize for 30 min followed by continuous superfusion with GLP-1 (1 nM), ivabradine (1 M), or GLP-1 + ivabradine

Ongoing lifestyle support can help maintain results

Rare but serious: severe low blood sugar, severe stomach pain that will not go away (possible pancreatitis), signs of thyroid tumor (lump in neck, hoarse voice, trouble swallowing)

Allowing the solution to warm slightly toward room temperature reduces the mild stinging sensation that very cold solution can produce during injection

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