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Early exploratory applications suggest it is generally well tolerated, with no reports of systemic adverse events or abnormal tissue reactions in available research contexts

doi: 10.1002/jmv.27405 181 MarM.de GregorioE.de DiosC.Roca-AgujetasV.CucarullB.TutusausA.et al

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Natural killer cells in multiple sclerosis: A review

Perez-Leighton, Butterick-Peterson, Billington, and Kotz (2013) proposed that throughout development of obesity, there are changes in orexinergic signaling, perhaps reducing orexinergic signaling gain by changes in synaptic plasticity, which continue to change orexin system responsiveness and promote further development of obesity

doi pubmed Kato M, Miwa Y, Tajika M, Hiraoka T, Muto Y, Moriwaki H