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Inhibition of the Xc-system, inactivation of GPX4 and overloading of iron ions are the three most critical factors leading to ferroptosis

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302 As discovered in 1986, this pathway facilitates the breakdown of proteins and nonprotein entities, such as subcellular organelles and pathogens, through N-degrons

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Thus, these related genes constitute a gene family, which includes at least 13 members that have been concisely summarized by Heisterkamp et al