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Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD et al (1994) Motor neuron degeneration in mice that express a human Cu Zn superoxide dismutase mutation

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Direct injection onto the powder cake creates turbulence and localized pressure that can break these bonds before they're fully solvated

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Dispense the diluent slowly along the inner wall of the vial never directly onto the powder