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Patients with existing heart or kidney disease may benefit from starting SGLT-2 inhibitors therapy, while those with a higher risk of developing these conditions, such as obese patients and those with no cardiogenic stroke, may benefit more from GLP-1 RAs

GLP-1s can be used to treat chronic weight management, especially for those living with obesity or who are overweight

Characterization and role of glucagon-like peptide 1 receptor in the lacrimal gland: novel insights into diabetic dry eye pathogenesis

This reduction causes afferent arteriole vasodilation, increasing the glomerular filtration rate

The authors had full editorial control of the manuscript and provided their final approval of all content

So it was very important for our chain of thought and decision early on that we actually knew that GLP-1 had these separate effects and that they could work in the brain and have a separate effect on well-known pathways in the brain