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coli in vivo

KPV has not been tested in pregnancy, breastfeeding, or in people on immune-modifying drugs, so those groups fall outside the evidence and have the most reason for caution

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Glia 68 , 12911303 (2020)

Notes: Chemically related to neostigmine, but has a longer duration of action and less GI effects Figure 2

1 Of those, 135 letters were based on an FDA inspection (inspection-based warning letters), including 16 letters issued to clinical investigators or sponsors following inspections conducted as part of the FDAs Bioresearch Monitoring (BIMO) Program