The new GLP-1 medications are very effective, and they have also made more people in medicine and outside of medicine aware of the harms that obesity can have
Renna shares why he shifted from managing diagnoses to building true patient partnerships, and how consistent rhythms in sleep, food, movement, and perspective can change the way you feel day to day
It has been shown that GLP-1RA semaglutide can improve working and spatial memory in transgenic AD modelling APP/PS1/tau (3xTg) mice, promote the release of anti-inflammatory factors and inhibit the production of pro-inflammatory factors in the cerebral cortex and hippocampus, as well as reduce the deposition of -amyloid in the CA1 subfield of the hippocampus
These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin
The secondary endpoint of fibrosis reduction by at least one stage was documented in 34%, 36%, and 34% of participants receiving survodutide compared to 22% of placebo, demonstrating potential anti-fibrotic benefit [23]
The only medication specifically approved for BED is lisdexamfetamine dimesylate (Vyvanse), a central nervous system stimulant approved in 2015 for moderate to severe BED in adults
