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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

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Hedlund contributed equally to this work

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DOI: 10.1210/jcem-73-1-213 70

The women given metformin or berberine had reductions in testosterone and insulin resistance, as well as increased pregnancy rates compared with those given placebo