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doi: 10.1016/j.biopha.2019.109470 127 ClevelandKHSchnellmannRG

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Cisplatin-Induced Nephrotoxicity Cisplatin is a chemotherapy drug that treats cancer by entering the tumor cells, releasing chloride ions, and becoming hydrated to crosslink with DNA and form DNA adducts to inhibit tumor cell replication [97,98]

The following are possible outcomes and benefits for individuals using tesofensine: Decrease in body weight and reduction in BMI Improvements in waist and hip circumference Decreased body fat Decreased visceral fat Decreased very-low-density lipoprotein & triglycerides Decreased insulin Better regulation of glucose metabolism Potential of reversing early type 2 diabetes In general, tesofensine is very well tolerated with few adverse effects and very similar to placebo