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2 Grip Strength and Exercise Endurance in Aged Mice Dimet-Wiley et al., Scientific Reports (2024) This study compared 5-Amino-1MQ treatment, voluntary wheel-running exercise (PoWeR), and combined treatment in aged C57BL/6J mice
The trade-off is more time off the peptide, but often better results during active cycles
5-Amino-1MQ has good oral absorption based on cell-uptake testing (Neelakantan 2018), and the typical 50 to 150 mg dose is far too large to inject comfortably
Moderate caloric restriction (15-20% below maintenance) supports AOD-9604 protocols without triggering metabolic adaptation or excessive muscle loss
They are not medical-use, diagnostic, or treatment claims
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