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The administration of cysteine-rich glutathione precursors, especially N-acetyl cysteine, has been shown to increase intracellular glutathione levels

I., Cuzi, S., Brajsa, K., Mildner, B., Bokuli, A., Situm, K., Perovi, D., Glojnari, I., & Parnham, M

The rate of permeation determined by efflux index method is usually described by efflux clearance ( Cl out ), which represents the net passage out of the brain and includes passive and active BBB transport as well as metabolism in the brain and elimination to the CSF by bulk flow (91)

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