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To summarize these mechanisms and their corresponding efficacy with GLP-1RAs or GLP-1, GLP-1RAs show the endothelial protective properties and thus owe to modulating vascular tone and maintaining endothelial barrier integrity, as well as the anti-adhesive and anti-thrombotic actions

Exendin 939 alleviates inflammatory and neuropathic chronic pain behaviors The analgesic potential of exendin 939 was confirmed in an acute pain mouse model, followed by an assessment of its effectiveness in a chronic pain model

According to research, aged garlic extract altered MetS patients adiponectin levels and upregulated Nrf-2 express,sion, which raised adiponectin after 12 weeks (239)

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But compared with catalpol, these compounds are still in the basic pharmacological research stage, and the transformation path from basic research to clinical trials needs a long time to explore and improve ( The main mechanisms of catalpol are mapped to different disease environments, showing similar regulatory effects, as shown in the Figure 8

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