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Irisin exerts beneficial effects on energy homeostasis [8], reduces systemic inflammation [9], modulates metabolic processes [10], and increases the whole body metabolic rate by inducing glucose transporter 4 (GLUT-4) expression and stimulating glycolysis in adipocytes [11]

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While it helps prevent blood sugar spikes after meals, metformin does not directly suppress appetite or trigger satiety signals in the brain

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