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On Period: 4 months at maintenance dose Off Period: 5 months with intensive lifestyle protocol Restart Trigger: Weight gain of 15 lb from maintenance weight Annual Cost Savings: 40 to 55 percent compared to continuous treatment The strategic cycling approach requires honest self assessment about lifestyle capacity during off periods

Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer

Dec 1 2018;103(12):4501-4510

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