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Additionally, gut commensals such as Butyricicoccus pullicaecorum , Butyrivibrio fibrisolvens , Ruminococcus bromii , and members of the family Lachnospiraceae also produce sodium butyrate upon fermenting dietary fibers, which inhibits CRC cell proliferation by regulating immune cells such as natural killer cells and macrophages, and causes apoptosis (Xi et al., 2021)
Postemsky PD, Palermo AM, Curvetto NR (2011) Protective effects of new medicinal mushroom, Grifola gargal singer (higher Basidiomycetes), on induced DNA damage in somatic cells of Drosophila melanogaster
doi: 10.1038/mp.2010.136
They've been built on decades of metabolic research, and a growing body of clinical data supports their effectiveness
Cells were treated with various concentrations of MG (1 M to 10 mM, diluted with water) for 24 h