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Animal studies showed retatrutide producing lower expression levels of inflammatory and fibrotic mediators compared to tirzepatide, suggesting the triple mechanism may offer benefits beyond additional weight loss

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Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

What the science actually says, briefly I have spent most of this piece on the cultural and economic story rather than the pharmacology, because I think the pharmacology has been written about extensively elsewhere and the structural story has not

We also summarize potential anti-lactylation drugs and their clinical impacts, with the aim of stimulating innovative research and facilitating the translation of lactylation-based machine learning, diagnosis, prognosis, and therapies into clinical practice