obesity drug news today glp-1 september 29 2025 How do weight-loss drugs work? What Ozempic and other GLP-1

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Dual GIP/GLP-1 Receptor Agonists Tirzepatide (Mounjaro) For Type 2 Diabetes Mounjaros May 13, 2022 approval introduced dual GIP/GLP 1 receptor agonism to type 2 diabetes treatment

Although albiglutide and dulaglutide, two high-molecular-weight GLP-1R agonists, both produce effective glycemic control in clinical studies, neither of these agents were as effective as liraglutide in generating weight loss in head-to-head studies that evaluated maximal doses of drugs approved for the treatment of diabetes (16, 17)

This article summarizes the receptor pharmacology, structural properties, and published study landscape for tirzepatide vs retatrutide , and outlines considerations for researchers selecting between them for protocol design