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Evidence for their potential application in AD and PD is strongest, with signals of target engagement in humans, while data in rarer disorders such as MSA, ALS, HD, and MS remain sparse and inconsistent

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HsrA belongs to the OmpR-like response regulator that acts as a transcription activator for itself and many others genes, including those involve in redox homeostasis, nitrogen metabolism, energy metabolism, and protein synthesis processes (Olekhnovich et al