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2 A common milieu of metabolic disorders in heart failure and cognitive impairment 2.1 Heart failure According to epidemiologic analyses, HF is highly prevalent in patients with type 2 diabetes, who are at a higher risk (up to 2-fold in men and 4-fold in women) of developing HF than patients without diabetes (Dunlay et al., 2019)

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However, the increased risk of congenital anomalies appears to be more related to hypertension itself, rather than drug exposure