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A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

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Research shows that even modest weight loss of 5-10% can reduce systolic blood pressure by 5-8 mmHg, which is part of why insurers view GLP-1 therapy as medically necessary for hypertensive patients with elevated BMI