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Clinical trials show average weight loss of 24.2% of body weight at standard doses over 48 weeks

Christensen M, Sparre-Ulrich AH, Hartmann B, et al

doi: 10.1186/s12933022-016047 86 DeVriesJHDesouzaCBellarySUngerJHansenOKHZachoJet al

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Over multiple punctures, these holes can fail to seal completely, allowing air exchange and potential contamination

Some blood pressure medications, birth control pills, and respiratory drugs may cause the problem