In the study of patients receiving Januvia as add-on combination therapy with metformin, there were no adverse reactions reported regardless of investigator assessment of causality in 5% of patients and more commonly than in patients given placebo
Thats a massive drop in inflammation
HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]
Diabetologia (2016) 59(2):26674.10.1007/s00125-015-3795-1 8 OdawaraMMiyagawaJIwamotoNTakitaYImaokaTTakamuraT
SBP, systolic blood pressure
Eli Lilly and Company, the developer of retatrutide, noted that both the 9 mg and 12 mg doses of retatrutide consistently outperformed placebo across all main efficacy measures