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demonstrated the involvement of the Wnt/-catenin and RANK/RANKL/(OPG) axis in PWS by showing high levels of RANK-L and low levels of OPG in both children and adults with PWS, with a bias towards RANK-L ( Recently, irisin, a myokine secreted by the muscle, has sparked great interest due to its involvement in bone, adipose tissue, and brain homeostasis

Common spots include the inner arm, shoulder, stomach, or hip

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