The glucagon-mediated thermogenesis likely accounts for slightly higher night sweat incidence early in treatment
Over-representation analysis of the DEGs was done by using ShinyGo 0.80 to show the top 20 pathways, ranked based on fold enrichment, and false discovery rate (FDR 0.05)
The most robust evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), in which retatrutide was evaluated over 48 weeks in adults with obesity but without type 2 diabetes
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By integrating the network graph and the topological attributes table, we identified five key targets associated with UC, including REN, LNPEP, HLA-A, OXTR, and SIRT1
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