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doi: 10.1056/NEJMoa2307983, 6 CasagrandeM.ForteG.FavieriF.CorboI

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In summary, the overwhelming production of ROS during MIRI, coupled with the depletion, inactivation, and dysregulation of the intrinsic antioxidant defense mechanisms and their regulatory pathways, leads to a state of severe redox imbalance