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Aldosterone acts on the mineralocorticoid receptors (MR) in the renal tubules, promoting sodium reabsorption and potassium excretion

Sublingual delivery does bypass gastric digestion, which is why it works well for small molecules like nitroglycerin or certain hormones

This effect is particularly relevant in hypogonadal models and aging populations where GH-axis activity declines

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TABLE 2 The Effect of 24 h Fasting on Ketones, Redox, and FFA [data from Blood Redox Metabolites Change Acutely as Illustrated in a Patient Fasted Overnight Then Fed High Glucose Changes in the L/P ratio, lactate plus pyruvate, the /A ratio, and total ketones occur rapidly in response to glucose feeding