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Indeed, several molecules have been implicated in the same direction regulation of APOC3 and APOA5 expression, including upregulation with hepatocyte nuclear factor 4- (HNF4-) [15, 16] and glucose [17, 18], and downregulation with AMP-activated protein kinase [15, 19], insulin [20,21,22] and tumor necrosis factor- (TNF-) [23, 24]

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