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Currently, key processes leading to neurodegeneration are considered to be oxidative stress, disruption of transition metal homeostasis, and inflammation of the nervous system

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Signalling functions of HDL are dependent on HDL binding to SR-B1 leading to the activation of the MAPK and PI3K-Akt signalling pathways [9]

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Cell Imaging/Staining In Vivo Efficacy Study Flow Cytometry Cell Proliferation/Viability Assay WB Biological Activity In Vitro Sertraline (1 M, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor- (TNF-)-induced microglial activation and inflammatory mediator production in microglia [3]

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