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These modifications result in a longer half-life (approximately 2030 hours) and reduced binding to IGF-binding proteins, making it about three times more potent than native IGF-1

This notion is speculative at present, as no change in cognition was observed in one small RCT of exenatide in schizophrenia 140 , while a positive cognitive effect of liraglutide was only seen in an even smaller non-randomized open-label investigation of people with either depressive or bipolar disorders 178,179

Nandam LS, Brazel M, Zhou M, Jhaveri DJ

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Likewise, through the amelioration of testicular oxidative stress status, enhancement of steroidogenic enzyme activity, and elevation of StAR gene expression, nano LC mitigated CYP-induced decline in testicular hormone levels 98