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That's a problem, since clinical data has shown that the majority of patients regain most of the weight they lost on a GLP-1 after they stop taking it
As for the DUAL-1 study, the primary endpoint was to prove non-inferiority of the combination compared to glargine and superiority compared to lixisenatide
Individual results vary significantly based on starting weight, adherence to lifestyle changes, and individual response to the medication
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The right treatment depends on whats actually causing the bulge: is it mainly fat, loose skin, muscle separation, or a combination
doi:10.1038/sj.onc.1208207
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