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In MDA-MB-231 cells, CuPDTC induces calpain-dependent PARP1 cleavage and apoptosis, and this process is reversed by calpastatin (a calpain inhibitor) (Milacic et al., 2008)

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160 These results indicated that LMP-1 has an anti-inflammatory effect against TNF- to maintain IVD possibly via ERK1/2 activation and NF-B inhibition

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