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Published work on intranasal peptide delivery (for insulin analogs, calcitonin, and oxytocin) demonstrates that bioavailability for this size class without enhancers is typically in the low single-digit percent range, though these data are from different peptides with different charge profiles

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While we typically get electrolytes through food and beverages, reduced food intake or increased fluid losses from GI side effects can make it harder to maintain that crucial balance

Mollan SP, Momin SNA, Khatkar PS, Grech O, Sinclair AJ, Tsermoulas G