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This 2024 guidance updates earlier interim recommendations from the American Society of Anesthesiologists (ASA) issued in 2023, which had suggested more routine holding of these medications (daily formulations on the day of procedure, weekly formulations for one week prior)
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Additionally, the altered gastrointestinal motility may affect the timing of food delivery to the small intestine where natural enzymes from the pancreas act
PMID: 10827002
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At multi-ton scale, the challenge becomes less about making the molecule and more about controlling the variability of the process in this interconnected system, explained Villain
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