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5.2 Cellular crosstalk Intestinal epithelial cells (IECs) constitute a critical physical barrier that segregates the intestinal lumen, with its diverse contents, including digested nutrients, commensal microbiota, and potential pathogens, from the underlying mucosal immune system (164)

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In the gastrointestinal tract and other tissues, GLP-1R can suppress gastric acid secretion and gastrointestinal motility, delay gastric emptying, enhance satiety, and reduce food intake