,
Consistent reduction in major cardiovascular events, even beyond glycaemic effects Meaningful kidney protection, slower eGFR decline & reduced albuminuria Benefits across phenotypes: diabetes, obesity, HFpEF, CKD & ASCVD A clear shift from organ-specific treatment to system-level risk reduction The next phase feels less about whether these agents work & more about who benefits most, when to start & how to integrate them alongside SGLT2 inhibitors and standard CV therapies
GLP-1 and GLP-1RA can regulate glucose levels, by stimulating insulin secretion and reducing the release of glucagon
The expression plasmid was transformed into E
References: Semaglutide Cardiovascular Outcomes Trials Lincoff AM, Brown-Frandsen K, Colhoun HM, et al
Serious but rare side effects such as acute pancreatitis and kidney failure apply to both forms