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On the other hand, Ab-CLP group maintained normal hematological parameters compared to sham group (Figures 2CF)

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism

Heliyon 2022;8:e11487

425,426 SIRT3 deficiency impairs the mitochondrial membrane potential, induces ROS accumulation, and triggers NLRP3 inflammasome activation, exacerbating cardiac damage

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Since SF3B1 phosphorylation occurs in tandem with the formation of a catalytically active U2/U6 RNA structure (i.e., from B to B act ) 8,12 , P-SF3B1 may also help to stabilize this structure during the activation process