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Some animal and early-phase studies noted elevated inflammatory cytokines (IL-6, TNF-) at higher doses, though clinical relevance in humans at therapeutic doses remains unclear

Whereas Ppg NTS-Abl increased body weight gain on transfer to an HFD, and GIPR-antag attenuated this effect, ablation of the Ppg neuronal population did not attenuate the effects of any treatment arm (Fig

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Cagrilintide is an investigational compound and not approved for individual use