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Trial reports show that gastrointestinal adverse events were most common during dose escalation and decreased over time

Barrera MJ, Aguilera S, Castro I, Corts J, Bahamondes V, Quest AFG, et al

On the data so far, yes, retatrutide takes off more at the top doses studied

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Peripheral neuropathy may take 36 months to improve, and some patients experience incomplete recovery, particularly if treatment was delayed