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Subsequently, Nrf2 translocates from cytoplasm to the nucleus, forming heterodimers with other proteins to bind to EpRE

36, Heilongjiang University of Chinese Medicine)

Supplementation of glutathione in all these systemic disorders has shown to have a therapeutic effect.[] GLUTATHIONE IN DERMATOLOGIC DISORDERS Glutathione is a key antioxidant and role of its reduced form as a skin lightening agent has been well studied

Statistical significance was calculated using two-sided Students t-test

Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis