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In 2023, the FDA added a new warning about the potential of ileus when taking semaglutide

Unlike prescription medications, dietary supplements such as Berberine are not approved by the U.S

2023;63(4S):s25-s30

Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway

According to Drucker the findings, published in December 2023, provided the first demonstration of 'a GLP-1-brain-immune axis that controls inflammation across the body independent of weight loss, even in peripheral organs devoid of GLP1 receptors.' Drucker's team has not yet identified which particular brain cells interact with GLP-1 (AAAS)

Most evidence comes from case reports and small observational studies, not randomized controlled trials